p-Y-STAT3 binds p-STAT5

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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Signal transducer and activator of transcription 3 (STAT3) is believed to bind Signal transducer and activator of transcription 5A/5B (STAT5). IL15 stimulation leads to the formation of DNA binding complexes that contain STAT3 and STAT5 (Johnston et al. 1995, Giron-Michel et al. 2003). This is a black box event because dimer formation is inferred from STAT3 and STAT5 co-occurrence in DNA binding complexes.

Literature References
PubMed ID Title Journal Year
12623850 Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules

van Dijk, M, Clay, D, Fogli, M, Chouaib, S, Bompais, H, Lebousse-Kerdilès, C, Briard, D, Ferrini, S, Azzarone, B, Meazza, R, Péault, B, Caignard, A, Brouty-Boyé, D, Giron-Michel, J

Blood 2003
7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

Ortaldo, JR, Finbloom, DS, Shibuya, K, Kaplan, D, Giri, JD, Bacon, CM, Chen, YQ, Gupta, S, Johnston, JA, Rees, RC

Proc Natl Acad Sci U S A 1995
Orthologous Events
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