p-Y-STAT3 binds p-STAT5

Stable Identifier
R-HSA-8983373
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Signal transducer and activator of transcription 3 (STAT3) is believed to bind Signal transducer and activator of transcription 5A/5B (STAT5). IL15 stimulation leads to the formation of DNA binding complexes that contain STAT3 and STAT5 (Johnston et al. 1995, Giron-Michel et al. 2003). This is a black box event because dimer formation is inferred from STAT3 and STAT5 co-occurrence in DNA binding complexes.

Literature References
PubMed ID Title Journal Year
7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

Johnston, JA, Bacon, CM, Finbloom, DS, Rees, RC, Kaplan, D, Shibuya, K, Ortaldo, JR, Gupta, S, Chen, YQ, Giri, JD

Proc Natl Acad Sci U S A 1995
12623850 Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules

Giron-Michel, J, Caignard, A, Fogli, M, Brouty-Boyé, D, Briard, D, van Dijk, M, Meazza, R, Ferrini, S, Lebousse-Kerdilès, C, Clay, D, Bompais, H, Chouaib, S, Péault, B, Azzarone, B

Blood 2003
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Orthologous Events
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Created