IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5

Stable Identifier
R-HSA-8983371
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Synonyms
STAT3 is phosphorylated after IL15-IL15 receptor interaction
ReviewStatus
5/5
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IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
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Signal transducer and activator of transcription 3 (STAT3) and Signal transducer and activator of transcription 5A or 5B (STAT5A,STAT5B or STAT5) are phosphorylated after Interleukin 15 (IL15) stimulation of the IL15 receptor complex (Johnston et al. 1995, Lin et al. 1995, Okada et al. 2015, Cooley et al. 2015, Krolopp et al. 2016), which consists of IL15, Interleukin-15 receptor subunit alpha (IL15RA, IL15Rα), Interleukin 2 receptor beta subunit (IL2RB, IL2Rβ), Tyrosine protein kinase JAK1 (JAK1), Cytokine receptor common subunit gamma (IL2RG, IL2Rγ) and Tyrosine protein kinase JAK3 (JAK3).<br>Treatment of human T cells with Interleukin 15 (IL15) and Interleukin 2 (IL2) resulted in the tyrosine phosphorylation of JAK1 and JAK3. Additionally, there was a rapid induction of DNA binding complexes that contained STAT3 and STAT5, both of which were tyrosine phosphorylated (Johnston et al. 1995).This is a black-box event because it is not clear which receptor-associated kinase is responsible for STAT phosphorylation.
Literature References
PubMed ID Title Journal Year
7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

Ortaldo, JR, Finbloom, DS, Shibuya, K, Kaplan, D, Giri, JD, Bacon, CM, Chen, YQ, Gupta, S, Johnston, JA, Rees, RC

Proc Natl Acad Sci U S A 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane]

Physical Entity
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
Activity
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Orthologous Events
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Bos taurus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Canis familiaris)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Mus musculus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Rattus norvegicus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Sus scrofa)
Authored
Duenas, C  (2017-08-07)
Reviewed
Patidar, M  (2017-08-07)
Created
Duenas, C  (2017-03-23)
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