Reactome | IL15 binds IL15RA

IL15 binds IL15RA

Stable Identifier

R-HSA-8983307

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

IL15 binds IL15 receptor alpha

ReviewStatus

5/5

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Interleukin 15 (IL15) binds Interleukin 15 receptor subunit alpha (IL15RA, IL15Rα). The high affinity Interleukin 15 receptor is a heterotrimer of IL15RA, Interleukin 2 receptor subunit beta (IL2RB, IL2Rβ, IL15RB) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ). IL15RA is structurally related to the alpha subunit of the Interleukin-2 receptor and determines high affinity binding for Interleukin 15 (IL15) (Giri et al. 1994, 1995, Anderson et al. 1995, Dubois et al. 2002). More in detail, IL15RA binds specifically to IL15 with high affinity (Kd=30-100 pM), whereas IL2RA specifically binds to IL2 with a comparatively lower affinity (Kd=10-30 nM) (Bernard et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
7641685	Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor Giri, JG, Kumaki, S, Ahdieh, M, Friend, DJ, Loomis, A, Shanebeck, K, DuBose, R, Cosman, D, Park, LS, Anderson, DM	EMBO J	1995
12433361	IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells Dubois, S, Mariner, J, Waldmann, TA, Tagaya, Y	Immunity	2002