IL15 binds IL15RA

Stable Identifier
R-HSA-8983307
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
IL15 binds IL15 receptor alpha
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin 15 (IL15) binds Interleukin 15 receptor subunit alpha (IL15RA, IL15Rα). The high affinity Interleukin 15 receptor is a heterotrimer of IL15RA, Interleukin 2 receptor subunit beta (IL2RB, IL2Rβ, IL15RB) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ). IL15RA is structurally related to the alpha subunit of the Interleukin-2 receptor and determines high affinity binding for Interleukin 15 (IL15) (Giri et al. 1994, 1995, Anderson et al. 1995, Dubois et al. 2002). More in detail, IL15RA binds specifically to IL15 with high affinity (Kd=30-100 pM), whereas IL2RA specifically binds to IL2 with a comparatively lower affinity (Kd=10-30 nM) (Bernard et al. 2004).

Literature References
PubMed ID Title Journal Year
12433361 IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

Dubois, S, Mariner, J, Waldmann, TA, Tagaya, Y

Immunity 2002
7641685 Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor

Giri, JG, Kumaki, S, Ahdieh, M, Friend, DJ, Loomis, A, Shanebeck, K, DuBose, R, Cosman, D, Park, LS, Anderson, DM

EMBO J 1995
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created