Tyrosine-protein kinase JAK1(JAK1) and Tyrosine-protein kinase JAK3 (JAK3) are believed to be phosphorylated after stimulation of the Interleukin-15 receptor complex by Interleukin-15 (IL15) (Johnston et al. 1995), though it has been reported that only JAK3 phosphorylation increases in response to IL15 (Krolopp et al. 2016). The Interleukin-15 receptor complex consists of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15Rα), Interleukin-2 receptor beta subunit (IL2RB, IL2Rβ), which is associated with JAK1 and Interleukin receptor gamma subunit, which is associated with JAK3 (Johnston et al. 1995). This is a black box event since the mechanism by which IL15 promotes JAK phosphorylation is unclear.
Ortaldo, JR, Finbloom, DS, Shibuya, K, Kaplan, D, Giri, JD, Bacon, CM, Chen, YQ, Gupta, S, Johnston, JA, Rees, RC
transmembrane receptor protein tyrosine kinase activity of IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane]
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