p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex

Stable Identifier
R-HSA-8983078
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Inferred from mouse:
Signal transducer and activator of transcription 5A, 5B (STAT5A and STAT5B) and Signal transducer and activator of transcription 3 (STAT3) are phosphorylated upon addition of human Thymic stromal lymphopoietin (TSLP) when both Cytokine receptor-like factor 2 (CRLF2) and Interleukin-7 Receptor (IL7R) are present (Reche et al. 2001). Subsequently the phosphorylated STATs dissociate.
This is black box event since as not been demonstrated experimentally.

Literature References
PubMed ID Title Journal Year
11418668 Human thymic stromal lymphopoietin preferentially stimulates myeloid cells

Reche, PA, Soumelis, V, Gorman, DM, Clifford, T, Liu, MR, Travis, M, Zurawski, SM, Johnston, J, Liu, YJ, Spits, H, de Waal Malefyt, R, Kastelein, RA, Bazan, JF

J. Immunol. 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created