STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex

Stable Identifier
R-HSA-8983059
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
TSLP:IL7R:CRLF2 phosphorylates STAT3
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Inferred from mouse:
Following binding of TSLP to Cytokine receptor-like factor 2 (CRLF2, TSLPR) and Interleukin-7 receptor subunit alpha (IL7R), Signal transducer and activator of transcription 5A and 5B (STAT5A and STAT5B) and Signal transducer and activator of transcription 3 (STAT3) were phosphorylated in various Ba/F3 cell populations (Reche et al. 2001).
This is a black box event since the kinase responsible for STAT phosphorylation is unknown.

Literature References
PubMed ID Title Journal Year
11418668 Human thymic stromal lymphopoietin preferentially stimulates myeloid cells

Reche, PA, Soumelis, V, Gorman, DM, Clifford, T, Liu, MR, Travis, M, Zurawski, SM, Johnston, J, Liu, YJ, Spits, H, de Waal Malefyt, R, Kastelein, RA, Bazan, JF

J. Immunol. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein kinase activity of IL7R:TSLP:CRLF2:STAT3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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