IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2

Stable Identifier
R-HSA-8983003
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Synonyms
IRS1/IRS2 binds IL7R complex
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Summation

Insulin receptor substrate 1 and 2 (IRS1, IRS2) bind to activated Interleukin-7 receptor complex . Interleukin-7 (IL7) stimulation of human thymocytes results in the rapid tyrosine phosphorylation of IRS1 and IRS2. This is a black box event because the kinase responsible for IRS phosphorylation is unclear.

Literature References
Participants
Participant Of
Orthologous Events
Authored
Reviewed