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IL2RG:p-JAK3
Stable Identifier
R-HSA-8982912
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RB and IL2RG are phosphorylated (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7R is phosphorylated on Y499 (Homo sapiens)
IL7:IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Homo sapiens)
IL7:IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
7719938
The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
Immunity
1995
Participants
components
IL2RG [plasma membrane] (Homo sapiens)
p-JAK3 [cytosol] (Homo sapiens)
Participant Of
hasComponent
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane]
IL7:IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane]
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane]
Inferred To
IL2RG:p-JAK3 [plasma membrane] (Bos taurus)
IL2RG:p-JAK3 [plasma membrane] (Canis familiaris)
IL2RG:p-JAK3 [plasma membrane] (Danio rerio)
IL2RG:p-JAK3 [plasma membrane] (Gallus gallus)
IL2RG:p-JAK3 [plasma membrane] (Mus musculus)
IL2RG:p-JAK3 [plasma membrane] (Rattus norvegicus)
IL2RG:p-JAK3 [plasma membrane] (Sus scrofa)
IL2RG:p-JAK3 [plasma membrane] (Taeniopygia guttata)
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