PGM2:Mg2+ isomerises dR1P to dR5P

Stable Identifier
R-HSA-8982667
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The nucleoside breakdown product deoxyribose-1-phosphate (dR1P) can be used to produce energy during oxidative or mitochondrial stress to minimize or delay stress-induced damage. Two steps connect this nucleoside breakdown product to central carbon metabolism in mammals. In the first step, dR1P is isomerised to the corresponding 5-phosphopentose, dR5P, mediated by phosphoglucomutase-2 (PGM2). PGM2 is a cytosolic, M2+-dependent enzyme that acts ten times better as a phosphopentomutase (both on R1P and dR1P) than as a phosphoglucomutase (on glucose-1-phosphate) (Maliekal et al. 2007).
Literature References
PubMed ID Title Journal Year
17804405 Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family

Maliekal, P, Veiga-da-Cunha, M, Sokolova, T, Van Schaftingen, E, Vertommen, D

J Biol Chem 2007
Participants
Participates
Catalyst Activity

phosphopentomutase activity of PGM2:Mg2+ [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!