PGM2:Mg2+ isomerises dR1P to dR5P

Stable Identifier
R-HSA-8982667
Type
Reaction
Species
Homo sapiens
Compartment
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The nucleoside breakdown product deoxyribose-1-phosphate (dR1P) can be used to produce energy during oxidative or mitochondrial stress to minimize or delay stress-induced damage. Two steps connect this nucleoside breakdown product to central carbon metabolism in mammals. In the first step, dR1P is isomerised to the corresponding 5-phosphopentose, dR5P, mediated by phosphoglucomutase-2 (PGM2). PGM2 is a cytosolic, M2+-dependent enzyme that acts ten times better as a phosphopentomutase (both on R1P and dR1P) than as a phosphoglucomutase (on glucose-1-phosphate) (Maliekal et al. 2007).

Literature References
PubMed ID Title Journal Year
17804405 Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family

Maliekal, P, Veiga-da-Cunha, M, Sokolova, T, Van Schaftingen, E, Vertommen, D

J Biol Chem 2007
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Catalyst Activity

phosphopentomutase activity of PGM2:Mg2+ [cytosol]

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