CYGB:O2 dissociates

Stable Identifier
R-HSA-8982617
Type
Reaction
Species
Homo sapiens
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At low oxygen concentrations cytoglobin:oxygen dissociates to yield free oxygen (O2) (Burmester et al. 2002, Trent and Hargrove 2002, Hamdane et al. 2003, Fago et al. 2004). The affinity of cytoglobin for oxygen is similar to the affinity of myoglobin for oxygen therefore cytoglobin is postulated to act similarly to myoglobin in transporting oxygen from regions of high concentration to regions of low concentration.

Literature References
PubMed ID Title Journal Year
14530264 The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin

Hankeln, T, Burmester, T, Pesce, A, Hamdane, D, Bolognesi, M, Kiger, L, Marden, MC, Uzan, J, Dewilde, S, Moens, L, Green, BN

J. Biol. Chem. 2003
11893755 A ubiquitously expressed human hexacoordinate hemoglobin

Hargrove, MS, Trent, JT

J. Biol. Chem. 2002
15299006 Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance

Gilany, K, Hundahl, C, Dewilde, S, Moens, L, Fago, A, Weber, RE

J. Biol. Chem. 2004
11919282 Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues

Hankeln, T, Burmester, T, Ebner, B, Weich, B

Mol. Biol. Evol. 2002
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