Reactome | CYGB:O2 dissociates

CYGB:O2 dissociates

Stable Identifier

R-HSA-8982617

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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At low oxygen concentrations cytoglobin:oxygen dissociates to yield free oxygen (O2) (Burmester et al. 2002, Trent and Hargrove 2002, Hamdane et al. 2003, Fago et al. 2004). The affinity of cytoglobin for oxygen is similar to the affinity of myoglobin for oxygen therefore cytoglobin is postulated to act similarly to myoglobin in transporting oxygen from regions of high concentration to regions of low concentration.

Literature References

PubMed ID	Title	Journal	Year
14530264	The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin Hamdane, D, Kiger, L, Dewilde, S, Green, BN, Pesce, A, Uzan, J, Burmester, T, Hankeln, T, Bolognesi, M, Moens, L, Marden, MC	J. Biol. Chem.	2003
11893755	A ubiquitously expressed human hexacoordinate hemoglobin Trent, JT, Hargrove, MS	J. Biol. Chem.	2002
15299006	Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance Fago, A, Hundahl, C, Dewilde, S, Gilany, K, Moens, L, Weber, RE	J. Biol. Chem.	2004
11919282	Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues Burmester, T, Ebner, B, Weich, B, Hankeln, T	Mol. Biol. Evol.	2002