Reactome | IL19:IL20RA:p‑JAK1:IL20RB binds STAT3

IL19:IL20RA:p‑JAK1:IL20RB binds STAT3

Stable Identifier

R-HSA-8982165

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

STAT3 binds to IL19:IL20RA:p-JAK1:IL20RB activated receptor complex, STAT3 binds to IL19-IL19 activated Receptor complex, STAT3 binds to IL19:IL20RA:p-JAK1:IL20RB

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Signal transducer and activator of transcription 3 (STAT3) is believed to bind the Interleukin-19 (IL19) /Interleukin-19 receptor complex. IL19 stimulates transient STAT3 phosphorylation and translocation from the cytoplasm to the nucleus (Dumoutier et al. 2001, Tian et al. 2008, Jain et al.2011). STAT3 binding is inferred to be a prerequisite for its phosphorylation from the signaling mechanism of the related interleukin-10 receptor, which is able to bind and phosphorylate STAT3 (Riley et al. 1999). The IL19 receptor complex consists of Interleukin-20 Receptor A (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor B (IL20RB). This is a black box event because binding of STAT3 after IL19 stimulus has not been demonstrated.

Literature References

PubMed ID	Title	Journal	Year
18669613	Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia Cuneo, A, Sommerville, LJ, Autieri, MV, Kelemen, SE, Tian, Y	Am. J. Pathol.	2008
11564763	Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types Renauld, JC, Kotenko, SV, Leemans, C, Dumoutier, L, Lejeune, D	J Immunol	2001
20966397	The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells Panetti, TS, Gabunia, K, Autieri, MV, Kelemen, SE, Jain, S	Arterioscler. Thromb. Vasc. Biol.	2011