IL19:IL20RA:p‑JAK1:IL20RB binds STAT3

Stable Identifier
R-HSA-8982165
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Synonyms
STAT3 binds to IL19:IL20RA:p-JAK1:IL20RB activated receptor complex, STAT3 binds to IL19-IL19 activated Receptor complex, STAT3 binds to IL19:IL20RA:p-JAK1:IL20RB
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IL19:IL20RA:p‑JAK1:IL20RB binds STAT3
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Signal transducer and activator of transcription 3 (STAT3) is believed to bind the Interleukin-19 (IL19) /Interleukin-19 receptor complex. IL19 stimulates transient STAT3 phosphorylation and translocation from the cytoplasm to the nucleus (Dumoutier et al. 2001, Tian et al. 2008, Jain et al.2011). STAT3 binding is inferred to be a prerequisite for its phosphorylation from the signaling mechanism of the related interleukin-10 receptor, which is able to bind and phosphorylate STAT3 (Riley et al. 1999). The IL19 receptor complex consists of Interleukin-20 Receptor A (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor B (IL20RB). This is a black box event because binding of STAT3 after IL19 stimulus has not been demonstrated.

Literature References
PubMed ID Title Journal Year
11564763 Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types

Dumoutier, L, Leemans, C, Lejeune, D, Kotenko, SV, Renauld, JC

J Immunol 2001
18669613 Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia

Tian, Y, Sommerville, LJ, Cuneo, A, Kelemen, SE, Autieri, MV

Am. J. Pathol. 2008
20966397 The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells

Jain, S, Gabunia, K, Kelemen, SE, Panetti, TS, Autieri, MV

Arterioscler. Thromb. Vasc. Biol. 2011
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Orthologous Events
IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Canis familiaris)
IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Danio rerio)
IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Gallus gallus)
IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Mus musculus)
IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Rattus norvegicus)
IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Xenopus tropicalis)
Authored
Duenas, C  (2017-03-16)
Reviewed
Datta, SK  (2017-11-15)
Created
Duenas, C  (2017-03-16)
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