IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3

Stable Identifier
Reaction [transition]
Homo sapiens
STAT3 is phosphorylated by IL19:IL20RA:p-JAK1:IL20RB:STAT3 activated receptor complex, STAT3 is phosphorylated by IL19/IL19 receptor activated complex
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Signal transducer and activator of transcription 3 (STAT3) is phosphorylated after Interleukin-19 (IL19) binds its receptor complex (Dumoutier et al. 2001, Tian et al. 2008, Jain et al.2011). The receptor complex consists of IL19, Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-20 receptor beta (IL20RB) and STAT3.

Literature References
PubMed ID Title Journal Year
18669613 Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia

Cuneo, A, Sommerville, LJ, Autieri, MV, Kelemen, SE, Tian, Y

Am. J. Pathol. 2008
11564763 Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types

Renauld, JC, Kotenko, SV, Leemans, C, Dumoutier, L, Lejeune, D

J Immunol 2001
20966397 The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells

Panetti, TS, Gabunia, K, Autieri, MV, Kelemen, SE, Jain, S

Arterioscler. Thromb. Vasc. Biol. 2011
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of IL19:IL20RA:p-JAK1:IL20RB:STAT3 [plasma membrane]

Orthologous Events
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