Reactome | IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3

IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3

Stable Identifier

R-HSA-8982163

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

STAT3 is phosphorylated by IL19:IL20RA:p-JAK1:IL20RB:STAT3 activated receptor complex, STAT3 is phosphorylated by IL19/IL19 receptor activated complex

ReviewStatus

5/5

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IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3

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Signal transducer and activator of transcription 3 (STAT3) is phosphorylated after Interleukin-19 (IL19) binds its receptor complex (Dumoutier et al. 2001, Tian et al. 2008, Jain et al.2011). The receptor complex consists of IL19, Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-20 receptor beta (IL20RB) and STAT3.

Literature References

PubMed ID	Title	Journal	Year
18669613	Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia Tian, Y, Sommerville, LJ, Cuneo, A, Kelemen, SE, Autieri, MV	Am. J. Pathol.	2008
11564763	Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types Dumoutier, L, Leemans, C, Lejeune, D, Kotenko, SV, Renauld, JC	J Immunol	2001
20966397	The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells Jain, S, Gabunia, K, Kelemen, SE, Panetti, TS, Autieri, MV	Arterioscler. Thromb. Vasc. Biol.	2011