Signal transducer and activator of transcription 3 (STAT3) is believed to dissociate from the Interleukin-19 (IL19) receptor complex after phosphorylation. The Interleukin-19 receptor complex is formed by Interleukin-20 receptor A (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor B (IL20RB). This is a black box event because dissociation of STAT3 from the IL19 receptor is inferred from IL-19 induced changed in STA3 regulated gene expression (Tian et al. 2008).
Cuneo, A, Sommerville, LJ, Autieri, MV, Kelemen, SE, Tian, Y
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