Reactome | p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB

p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB

Stable Identifier

R-HSA-8982162

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

p-Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB:p-Y705, p-Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB:p-Y705-STAT3 activated receptor complex, p-Y705-STAT3 dissociates from IL19/IL19 receptor activated complex, p-Y705-STAT3 dissociates from IL20RA:IL20RB:IL19,IL20,IL24:p-Y705-STAT3

ReviewStatus

5/5

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p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB

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Signal transducer and activator of transcription 3 (STAT3) is believed to dissociate from the Interleukin-19 (IL19) receptor complex after phosphorylation. The Interleukin-19 receptor complex is formed by Interleukin-20 receptor A (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor B (IL20RB). This is a black box event because dissociation of STAT3 from the IL19 receptor is inferred from IL-19 induced changed in STA3 regulated gene expression (Tian et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18669613	Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia Cuneo, A, Sommerville, LJ, Autieri, MV, Kelemen, SE, Tian, Y	Am. J. Pathol.	2008