Reactome | Myoglobin:oxygen dissociates

Myoglobin:oxygen dissociates

Stable Identifier

R-HSA-8981622

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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When the concentration of oxygen is low myoglobin:oxygen dissociates to yield free oxygen (Rossi-Fanelli and Antonini 1958, Boulton and Huntsman 1972, Wang et al. 2004). The dissociation constant is about 1 micromole per liter. Myoglobin:oxygen may also transfer oxygen directly to cytochrome oxidase of mitochondria (inferred from rat homologs in Yamada et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
5032105	Variants of human myoglobin: their oxygen dissociation curves Boulton, FE, Huntsman, RG	Br. J. Haematol.	1972
15601759	Human myoglobin recognition of oxygen: dynamics of the energy landscape Baskin, JS, Zewail, AH, Xia, T, Wang, Y	Proc. Natl. Acad. Sci. U.S.A.	2004
13584010	Studies on the oxygen and carbon monoxide equilibria of human myoglobin ROSSI-FANELLI, A, ANTONINI, E	Arch. Biochem. Biophys.	1958
23195625	Interaction between myoglobin and mitochondria in rat skeletal muscle Hashimoto, T, Takakura, H, Hanai, Y, Furuichi, Y, Jue, T, Masuda, K, Yamada, T	J. Appl. Physiol.	2013