Reactome | Neuroglobin binds oxygen

Neuroglobin binds oxygen

Stable Identifier

R-HSA-8981610

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Neuroglobin binds molecular oxygen (O2) in neurons of the central nervous system and peripheral nervous system (Burmester et al. 2000, Dewilde et al. 2001, Trent et al. 2001, Orlowski and Nowak 2008, Bocahut et al. 2009, Watanabe et al. 2012, Hundahl et al. 2013). An elongated cavity in the protein may facilitate the diffusion of oxygen to the heme (Pesce et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
11429401	Human neuroglobin, a hexacoordinate hemoglobin that reversibly binds oxygen Watts, RA, Hargrove, MS, Trent, JT	J. Biol. Chem.	2001
19919085	Relating the diffusion of small ligands in human neuroglobin to its structural and mechanical properties Bernad, S, Bocahut, A, Sebban, P, Sacquin-Mora, S	J Phys Chem B	2009
11029004	A vertebrate globin expressed in the brain Reinhardt, S, Weich, B, Hankeln, T, Burmester, T	Nature	2000
22787149	Human neuroglobin functions as an oxidative stress-responsive sensor for neuroprotection Wakasugi, K, Watanabe, S, Uchida, H, Takahashi, N	J. Biol. Chem.	2012
18718500	Topology and thermodynamics of gaseous ligands diffusion paths in human neuroglobin Orlowski, S, Nowak, W	BioSystems	2008
23160832	Neuroglobin and cytoglobin expression in the human brain Hay-Schmidt, A, Hundahl, CA, Kelsen, J	Brain Struct Funct	2013
12962627	Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity Hankeln, T, Ascenzi, P, Burmester, T, Pesce, A, Bolognesi, M, Dewilde, S, Moens, L, Nardini, M	Structure	2003
11473128	Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family Baudin-Creuza, V, Dewilde, S, Aerts, T, Moens, L, Marden, MC, Kiger, L, Hankeln, T, Caubergs, R, Burmester, T	J. Biol. Chem.	2001