Neuroglobin binds oxygen

Stable Identifier
Reaction [binding]
Homo sapiens
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Neuroglobin binds molecular oxygen (O2) in neurons of the central nervous system and peripheral nervous system (Burmester et al. 2000, Dewilde et al. 2001, Trent et al. 2001, Orlowski and Nowak 2008, Bocahut et al. 2009, Watanabe et al. 2012, Hundahl et al. 2013). An elongated cavity in the protein may facilitate the diffusion of oxygen to the heme (Pesce et al. 2003).
Literature References
PubMed ID Title Journal Year
11429401 Human neuroglobin, a hexacoordinate hemoglobin that reversibly binds oxygen

Watts, RA, Hargrove, MS, Trent, JT

J. Biol. Chem. 2001
19919085 Relating the diffusion of small ligands in human neuroglobin to its structural and mechanical properties

Bernad, S, Bocahut, A, Sebban, P, Sacquin-Mora, S

J Phys Chem B 2009
11029004 A vertebrate globin expressed in the brain

Reinhardt, S, Weich, B, Hankeln, T, Burmester, T

Nature 2000
22787149 Human neuroglobin functions as an oxidative stress-responsive sensor for neuroprotection

Wakasugi, K, Watanabe, S, Uchida, H, Takahashi, N

J. Biol. Chem. 2012
18718500 Topology and thermodynamics of gaseous ligands diffusion paths in human neuroglobin

Orlowski, S, Nowak, W

BioSystems 2008
23160832 Neuroglobin and cytoglobin expression in the human brain

Hay-Schmidt, A, Hundahl, CA, Kelsen, J

Brain Struct Funct 2013
12962627 Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity

Hankeln, T, Ascenzi, P, Burmester, T, Pesce, A, Bolognesi, M, Dewilde, S, Moens, L, Nardini, M

Structure 2003
11473128 Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family

Baudin-Creuza, V, Dewilde, S, Aerts, T, Moens, L, Marden, MC, Kiger, L, Hankeln, T, Caubergs, R, Burmester, T

J. Biol. Chem. 2001
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