GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol

Stable Identifier
R-HSA-8981564
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol
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Tetrameric GLUT3, the SLC2A3 gene product, associated with the plasma membrane, mediates the facilitated diffusion of glucose (Glc) into cells. GLUT3 is expressed by many cell types, notably in the brain. Its low Km for glucose (~1 mM) relative to normal blood glucose concentration (~5 mM) allows these cells to import glucose independent of fluctuations in blood glucose levels (Colville et al. 1993). GLUT3, like GLUT1 and 4, has a high affinity for glucose.
Literature References
PubMed ID Title Journal Year
8457197 Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors

Gould, GW, Colville, CA, Seatter, MJ, Thomas, HM, Jess, TJ

Biochem J 1993
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Event Information
Go Biological Process
D-glucose transmembrane transport (1904659)
Catalyst Activity

D-glucose transmembrane transporter activity of GLUT3 / SLC2A3 tetramer [plasma membrane]

Physical Entity
GLUT3 / SLC2A3 tetramer [plasma membrane] (Homo sapiens)
Activity
D-glucose transmembrane transporter activity (GO:0055056)
Orthologous Events
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Bos taurus)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Danio rerio)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Mus musculus)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)
GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)
Authored
D'Eustachio, P  (2004-06-23)
Reviewed
He, L  (2009-08-24)
Created
D'Eustachio, P  (2017-03-11)
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