GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol

Stable Identifier
R-HSA-8981564
Type
Reaction [transition]
Species
Homo sapiens
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Tetrameric GLUT3, the SLC2A3 gene product, associated with the plasma membrane, mediates the facilitated diffusion of glucose (Glc) into cells. GLUT3 is expressed by many cell types, notably in the brain. Its low Km for glucose (~1 mM) relative to normal blood glucose concentration (~5 mM) allows these cells to import glucose independent of fluctuations in blood glucose levels (Colville et al. 1993). GLUT3, like GLUT1 and 4, has a high affinity for glucose.

Literature References
PubMed ID Title Journal Year
8457197 Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors

Colville, CA, Seatter, MJ, Jess, TJ, Gould, GW, Thomas, HM

Biochem J 1993
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Catalyst Activity
Title
D-glucose transmembrane transporter activity of GLUT3 / SLC2A3 tetramer [plasma membrane]
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