GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol

Stable Identifier
R-HSA-8981553
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol
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The SLC2A14 gene appears to have arisen by duplication of the SLC2A3 gene. It is expressed only in testis. The GLUT14 / SLC2A14 protein product has not been characterized but is inferred based on sequence similarity to exist as a plasma membrane associated tetramer that mediates the facilitated diffusion of glucose (Glc) into cells (Wu & Freeze 2002).
Literature References
PubMed ID Title Journal Year
12504846 GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms

Freeze, HH, Wu, X

Genomics 2002
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Output
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Event Information
Go Biological Process
D-glucose transmembrane transport (1904659)
Catalyst Activity

D-glucose transmembrane transporter activity of GLUT14 / SLC2A14 tetramer [plasma membrane]

Physical Entity
GLUT14 / SLC2A14 tetramer [plasma membrane] (Homo sapiens)
Activity
D-glucose transmembrane transporter activity (GO:0055056)
Orthologous Events
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Bos taurus)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Danio rerio)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Mus musculus)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)
GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)
Authored
D'Eustachio, P  (2004-06-23)
Reviewed
He, L  (2009-08-24)
Created
D'Eustachio, P  (2017-03-11)
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