CIT-3 binds activated RHOA, RHOB, RHOC and RAC1

Stable Identifier
R-HSA-8981443
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
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The neuronally expressed CIT isoform, CIT-3 (CIT-N), lacks the kinase domain but retains the RHO GTPase binding domain (Di Cunto et al. 1998) and can bind to activated GTP-bound RHOA, RHOB, RHOC and RAC1.

Literature References
PubMed ID Title Journal Year
9792683 Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron

Di Cunto, F, Calautti, E, Hsiao, J, Ong, L, Topley, G, Turco, E, Dotto, GP

J. Biol. Chem. 1998
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Cit-3 binds activated Rhoa, Rhob, Rhoc and Rac1 (Mus musculus)
Cross References
Target Pathogen
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2017-03-08)
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