CIT-3 binds activated RHOA, RHOB, RHOC and RAC1

Stable Identifier
R-HSA-8981443
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
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The neuronally expressed CIT isoform, CIT-3 (CIT-N), lacks the kinase domain but retains the RHO GTPase binding domain (Di Cunto et al. 1998) and can bind to activated GTP-bound RHOA, RHOB, RHOC and RAC1.

Literature References
PubMed ID Title Journal Year
9792683 Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron

Calautti, E, Turco, E, Di Cunto, F, Ong, L, Dotto, GP, Topley, G, Hsiao, J

J. Biol. Chem. 1998
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Inferred From
Cit-3 binds activated Rhoa, Rhob, Rhoc and Rac1 (Mus musculus)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2017-03-08)
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