IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [cytosol]

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Transfected COS cells express the Interleukin-12 receptor subunit both as monomers, and the dimerization or oligomerization of both receprots does not depend on Interleukin-12 binding. Anyway if Interleukin-12 is prebound to these cells, the resulting banding pattern does not change (PMID:7911493)

Literature References
PubMed ID Title Journal Year
12893768 In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment

Durali, D, de Goër de Herve, MG, Giron-Michel, J, Azzarone, B, Delfraissy, JF, Taoufik, Y

Blood 2003
7911493 Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130

Chua, AO, Chizzonite, R, Desai, BB, Truitt, TP, Nunes, P, Minetti, LJ, Warrier, RR, Presky, DH, Levine, JF, Gately, MK

J. Immunol. 1994
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