LIPs hydrolyze TG to DAG and LCFA

Stable Identifier
R-HSA-8979996
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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LIPs hydrolyze TG to DAG and LCFA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Lipases are enzymes that hydrolyse dietary lipids such as fats, oils and triglycerides. The majority of human lipases are secreted by the pancreas and function mainly in the digestive system. Humans not only digest fat with pancreatic lipases but also with gastric lipase (LIPF) (Roussel et al. 1999). The pancreatic lipase-related protein 3 (PNLIPRP3) is another candidate lipase included here.
Literature References
PubMed ID Title Journal Year
10358049 Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest

Egloff, MP, Rivière, M, Cambillau, C, Roussel, A, Dupuis, L, Verger, R, Canaan, S

J. Biol. Chem. 1999
Participants
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Output
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as an event of
Catalyst Activity

lipoprotein lipase activity of digestive LIPs [extracellular region]

Physical Entity
digestive LIPs [extracellular region] (Homo sapiens)
Activity
lipoprotein lipase activity (GO:0004465)
Orthologous Events
LIPs hydrolyze TG to DAG and LCFA (Bos taurus)
LIPs hydrolyze TG to DAG and LCFA (Canis familiaris)
LIPs hydrolyze TG to DAG and LCFA (Dictyostelium discoideum)
LIPs hydrolyze TG to DAG and LCFA (Mus musculus)
LIPs hydrolyze TG to DAG and LCFA (Plasmodium falciparum)
LIPs hydrolyze TG to DAG and LCFA (Rattus norvegicus)
LIPs hydrolyze TG to DAG and LCFA (Saccharomyces cerevisiae)
LIPs hydrolyze TG to DAG and LCFA (Schizosaccharomyces pombe)
Authored
Jassal, B  (2015-07-30)
Reviewed
D'Eustachio, P  (2015-09-14)
Created
D'Eustachio, P  (2017-02-27)
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