MYBL2 gene expression is inhibited by RBL1 and RBL2

Stable Identifier
R-HSA-8978926
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MYBL2 gene expression is inhibited by RBL1 and RBL2
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In G0 and early G1, complexes containing p130 (RBL2) and p107 (RBL1), respectively, and histone deacetylase HDAC1 directly inhibit transcription from the MYBL2 gene (Rayman et al. 2002).

Literature References
PubMed ID Title Journal Year
11959842 E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

Catchpole, S, Dynlacht, BD, te Riele, H, Dannenberg, JH, Watson, RJ, Rayman, JB, Indjeian, VB, Takahashi, Y

Genes Dev 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:MYBL2 gene [nucleoplasm] (Homo sapiens)
Active Unit
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm]
Inferred From
Mybl2 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1 (Mus musculus)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2017-02-21)
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