PAK1 binds ARHGEF6

Stable Identifier
R-HSA-8964619
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. Serine/threonine-protein kinase PAK 1 can directly bind with Rho guanine nucleotide exchange factor 6 (ARHGEF6, PIX-Alpha) in the cytosol. This complex is then translocated to the plasma membrane where Cell division control protein 42 homolog (CDC42) is activated. CDC42 is known to be involved in epithelial cell polarization processes.

Literature References
PubMed ID Title Journal Year
12887923 Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42

Li, Z, Hannigan, M, Mo, Z, Liu, B, Lu, W, Wu, Y, Smrcka, AV, Wu, G, Li, L, Liu, M, Huang, CK, Wu, D

Cell 2003
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