PAK1:ARHGEF6 complex binds G-protein beta-gamma complex

Stable Identifier
Reaction [binding]
Homo sapiens
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. Serine/threonine-protein kinase PAK 1 binds with Rho guanine nucleotide exchange factor 6 (ARHGEF6, PIX-Alpha) in the cytosol. PAK1 in this complex then binds to G-protein beta-gamma complex and facilitates the translocation of PAK1:ARHGEF6 complex to the plasma membrane, where Cell division control protein 42 homolog (CDC42) is activated. CDC42 is known to be involved in epithelial cell polarization processes.

Literature References
PubMed ID Title Journal Year
12887923 Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42

Wu, Y, Li, Z, Mo, Z, Smrcka, AV, Huang, CK, Liu, B, Lu, W, Wu, G, Wu, D, Li, L, Liu, M, Hannigan, M

Cell 2003
Orthologous Events
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