TOP2A gene gene expression is repressed by the DREAM complex

Stable Identifier
R-HSA-8964531
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TOP2A gene gene expression is repressed by the DREAM complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The DREAM complex directly represses the TOP2A gene transcription (Litovchick et al. 2007).

Literature References
PubMed ID Title Journal Year
17531812 Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

Litovchick, L, Sadasivam, S, Florens, LA, Zhu, X, Swanson, SK, Velmurugan, S, Chen, R, Washburn, MP, Liu, XS, DeCaprio, JA

Mol Cell 2007
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Negatively by
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2017-02-17)
Cite Us!