TOP2A gene gene expression is repressed by the DREAM complex

Stable Identifier
R-HSA-8964531
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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TOP2A gene gene expression is repressed by the DREAM complex
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The DREAM complex directly represses the TOP2A gene transcription (Litovchick et al. 2007).

Literature References
PubMed ID Title Journal Year
17531812 Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

DeCaprio, JA, Washburn, MP, Swanson, SK, Zhu, X, Florens, LA, Chen, R, Litovchick, L, Liu, XS, Sadasivam, S, Velmurugan, S

Mol Cell 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
DREAM complex:TOP2A gene [nucleoplasm] (Homo sapiens)
Active Unit
DREAM complex [nucleoplasm]
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2017-02-17)
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