G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC

Stable Identifier
R-HSA-8964329
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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G-Protein Coupled Receptors sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(i) subunit alpha (GNAI) can directly bind to proto-oncogene tyrosine-protein kinase Src (SRC). When bound to active GNAI, SRC can autophosphorylate the 416-tyrosine residue. Upon autophosphorylation, SRC dissociates from GNAI and is subsequently activated. GNAI increases SRC enzymatic activity by decreasing Km and not affecting Vm. Physiologically, the SRC family have implications in cell growth and cancer.

Literature References
PubMed ID Title Journal Year
11007482 Src tyrosine kinase is a novel direct effector of G proteins

Ma, YC, Huang, J, Ali, S, Lowry, W, Huang, XY

Cell 2000
Participants
Participant Of
Orthologous Events
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Created