G alpha (i):GTP binds SRC

Stable Identifier
R-HSA-8964311
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(i) subunit alpha (GNAI) can bind directly to proto-oncogene tyrosine-protein kinase Src (SRC) in vitro and in vivo. This binding results in autophosphorylation of SRC and subsequently its activation. Physiologically, the SRC family have implications in cell growth and cancer.

Literature References
PubMed ID Title Journal Year
11007482 Src tyrosine kinase is a novel direct effector of G proteins

Ma, YC, Huang, J, Ali, S, Lowry, W, Huang, XY

Cell 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created