G alpha (s):GTP:SRC dissociates

Stable Identifier
R-HSA-8964287
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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G alpha (s):GTP:SRC dissociates
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Upon autophosphorylation, SRC dissociates from GNAS and is subsequently activated. GNAS increases SRC enzymatic activity by decreasing Km and not affecting Vm. Physiologically, the SRC family have implications in cell growth and cancer.
Literature References
PubMed ID Title Journal Year
11007482 Src tyrosine kinase is a novel direct effector of G proteins

Lowry, W, Ali, S, Huang, XY, Huang, J, Ma, YC

Cell 2000
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Output
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as an event of
Authored
Varusai, TM  (2017-07-27)
Reviewed
Huang, X  (2018-09-13)
Created
Varusai, TM  (2017-02-16)
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