BTK in PIP3:BTK:G beta-gamma complex is activated

Stable Identifier
R-HSA-8964271
Type
Reaction [transition]
Species
Homo sapiens
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. G-protein beta-gamma complex, along with phosphatidylinositol 3,4,5-trisphosphate (PIP3), recruits the non-receptor Tyrosine-protein kinase BTK to the cell membrane. In the membrane, the G-protein beta-gamma complex binds to the catalytic domain of BTK and activates it. Active BTK is then released to the cytoplasm. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

Literature References
PubMed ID Title Journal Year
11742120 Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization

Laederach, A, Cradic, KW, Brazin, KN, Zamoon, J, Fulton, DB, Huang, XY, Andreotti, AH

Protein Sci. 2002
11698416 G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase

Lowry, WE, Huang, XY

J. Biol. Chem. 2002
7567982 Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits

Langhans-Rajasekaran, SA, Wan, Y, Huang, XY

Proc. Natl. Acad. Sci. U.S.A. 1995
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