Reactome | BTK in PIP3:BTK:G beta-gamma complex is activated

BTK in PIP3:BTK:G beta-gamma complex is activated

Stable Identifier

R-HSA-8964271

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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BTK in PIP3:BTK:G beta-gamma complex is activated

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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. G-protein beta-gamma complex, along with phosphatidylinositol 3,4,5-trisphosphate (PIP3), recruits the non-receptor Tyrosine-protein kinase BTK to the cell membrane. In the membrane, the G-protein beta-gamma complex binds to the catalytic domain of BTK and activates it. Active BTK is then released to the cytoplasm. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

Literature References

PubMed ID	Title	Journal	Year
11698416	G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase Lowry, WE, Huang, XY	J. Biol. Chem.	2002
11742120	Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization Laederach, A, Cradic, KW, Brazin, KN, Zamoon, J, Fulton, DB, Huang, XY, Andreotti, AH	Protein Sci.	2002
7567982	Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits Langhans-Rajasekaran, SA, Wan, Y, Huang, XY	Proc. Natl. Acad. Sci. U.S.A.	1995