LDL remodeling

Stable Identifier
R-HSA-8964041
Type
Pathway
Species
Homo sapiens
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LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. CETP (cholesterol ester transfer protein) complexed with cholesterol esters interacts with an LDL (low density lipoprotein) particle, acquiring triacylglycerol molecules and donating cholesterol ester to the LDL (Swenson et al. 1988; Morton & Zilversmit 1983), a key step in the transport of tissue cholesterol to the liver.
As an alternative to LDLR-mediated uptake and degradation, a LDL particle can bind a single molecule of LPA (apolipoprotein A), forming a Lp(a) lipoprotein particle (Lobentanz et al. 1998).

Literature References
PubMed ID Title Journal Year
2833496 Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids

Swenson, TL, Brocia, RW, Tall, AR

J Biol Chem 1988
6619141 Inter-relationship of lipids transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma

Morton, RE, Zilversmit, DB

J Biol Chem 1983
9548923 Intracellular metabolism of human apolipoprotein(a) in stably transfected Hep G2 cells

Lobentanz, EM, Krasznai, K, Gruber, A, Brunner, C, Muller, HJ, Sattler, J, Kraft, HG, Utermann, G, Dieplinger, H

Biochemistry 1998
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