Reactome | LDL remodeling

LDL remodeling

Stable Identifier

R-HSA-8964041

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. CETP (cholesterol ester transfer protein) complexed with cholesterol esters interacts with an LDL (low density lipoprotein) particle, acquiring triacylglycerol molecules and donating cholesterol ester to the LDL (Swenson et al. 1988; Morton & Zilversmit 1983), a key step in the transport of tissue cholesterol to the liver.
As an alternative to LDLR-mediated uptake and degradation, a LDL particle can bind a single molecule of LPA (apolipoprotein A), forming a Lp(a) lipoprotein particle (Lobentanz et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
6619141	Inter-relationship of lipids transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma Morton, RE, Zilversmit, DB	J Biol Chem	1983
2833496	Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids Swenson, TL, Brocia, RW, Tall, AR	J Biol Chem	1988
9548923	Intracellular metabolism of human apolipoprotein(a) in stably transfected Hep G2 cells Lobentanz, EM, Krasznai, K, Gruber, A, Brunner, C, Muller, HJ, Sattler, J, Kraft, HG, Utermann, G, Dieplinger, H	Biochemistry	1998