Reactome | CUBN dissociates from 25(OH)D

CUBN dissociates from 25(OH)D

Stable Identifier

R-HSA-8963864

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

lysosomal lumen

ReviewStatus

5/5

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Cubilin (CUBN), once released from the complex, cycles back to the cell surface. Free 25-hydroxyvitamin D (calcidiol, 25(OH)D) becomes available for further processing (Nykjaer et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10052453	An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3 Melsen, F, Christensen, EI, Jacobsen, C, Vorum, H, Nykjaer, A, Willnow, TE, Herz, J, Walther, D, Dragun, D	Cell	1999