TK1 gene expression is stimulated by E2F1

Stable Identifier
R-HSA-8962039
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TK1 gene expression is stimulated by E2F1
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E2F1 directly stimulates transcription of the TK1 gene, encoding thymidine kinase (Dou et al. 1994, DeGregori et al. 1995, Giangrande et al. 2004).
Literature References
PubMed ID Title Journal Year
15014447 Combinatorial gene control involving E2F and E Box family members

Laakso, N, Nevins, JR, Rempel, RE, Zhu, W, Giangrande, PH

EMBO J. 2004
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

Nevins, JR, DeGregori, J, Kowalik, T

Mol Cell Biol 1995
8288595 G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter

Wang, J, Dou, QP, Pardee, AB, Zhao, S, Helin, K, Levin, AH

J. Biol. Chem. 1994
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
E2F1:TFDP1,TFDP2:TK1 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:TFDP1,TFDP2 [nucleoplasm]
Inferred From
Tk1 gene expression is stimulated by E2F1 (Mus musculus)
Authored
Gopinathrao, G  (2004-06-16)
Reviewed
Bosco, G  (2004-06-16)
Created
Orlic-Milacic, M  (2017-02-07)
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