E2F1 directly stimulates transcription of the RRM2 gene, encoding Ribonucleoside-diphosphate reductase subunit M2 (DeGregori et al. 1995, Giangrande et al. 2004). Binding of E2F6 to the RRM2 gene promoter inhibits RRM2 transcription (Bertoli et al. 2013).
Bertoli, C, Klier, S, McGowan, C, Wittenberg, C, de Bruin, RA
Giangrande, PH, Zhu, W, Rempel, RE, Laakso, N, Nevins, JR
DeGregori, J, Kowalik, T, Nevins, JR
© 2021 Reactome