RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6

Stable Identifier
R-HSA-8961982
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6
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E2F1 directly stimulates transcription of the RRM2 gene, encoding Ribonucleoside-diphosphate reductase subunit M2 (DeGregori et al. 1995, Giangrande et al. 2004). Binding of E2F6 to the RRM2 gene promoter inhibits RRM2 transcription (Bertoli et al. 2013).

Literature References
PubMed ID Title Journal Year
15014447 Combinatorial gene control involving E2F and E Box family members

Laakso, N, Nevins, JR, Rempel, RE, Zhu, W, Giangrande, PH

EMBO J. 2004
23954429 Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription

Bertoli, C, McGowan, C, Klier, S, Wittenberg, C, de Bruin, RA

Curr. Biol. 2013
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

Nevins, JR, DeGregori, J, Kowalik, T

Mol Cell Biol 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
E2F6:(TFDP1,TFDP2):RRM2 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F6:(TFDP1,TFDP2) [nucleoplasm]
Positively by
Regulator
E2F1:TFDP1,TFDP2:RRM2 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:TFDP1,TFDP2 [nucleoplasm]
Authored
Gopinathrao, G  (2004-06-16)
Reviewed
Herlihy, A  (2017-05-12)
Bosco, G  (2004-06-16)
Created
Orlic-Milacic, M  (2017-02-06)
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