Reactome | RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6

RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6

Stable Identifier

R-HSA-8961982

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

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RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6

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E2F1 directly stimulates transcription of the RRM2 gene, encoding Ribonucleoside-diphosphate reductase subunit M2 (DeGregori et al. 1995, Giangrande et al. 2004). Binding of E2F6 to the RRM2 gene promoter inhibits RRM2 transcription (Bertoli et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23954429	Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription Bertoli, C, Klier, S, McGowan, C, Wittenberg, C, de Bruin, RA	Curr. Biol.	2013
15014447	Combinatorial gene control involving E2F and E Box family members Giangrande, PH, Zhu, W, Rempel, RE, Laakso, N, Nevins, JR	EMBO J.	2004
7623816	Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes DeGregori, J, Kowalik, T, Nevins, JR	Mol Cell Biol	1995