RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6

Stable Identifier
R-HSA-8961982
Type
Reaction [omitted]
Species
Homo sapiens
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E2F1 directly stimulates transcription of the RRM2 gene, encoding Ribonucleoside-diphosphate reductase subunit M2 (DeGregori et al. 1995, Giangrande et al. 2004). Binding of E2F6 to the RRM2 gene promoter inhibits RRM2 transcription (Bertoli et al. 2013).

Literature References
PubMed ID Title Journal Year
23954429 Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription

Bertoli, C, Klier, S, McGowan, C, Wittenberg, C, de Bruin, RA

Curr. Biol. 2013
15014447 Combinatorial gene control involving E2F and E Box family members

Giangrande, PH, Zhu, W, Rempel, RE, Laakso, N, Nevins, JR

EMBO J. 2004
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

DeGregori, J, Kowalik, T, Nevins, JR

Mol Cell Biol 1995
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