E2F1 directly stimulates transcription of the DHFR gene, encoding dihydrofolate reductase. DHFR is involved in folate metabolism and synthesis of DNA bases (DeGregori et al. 1995, Wells et al. 1997, Darbinian et al. 1999).
Nevins, JR, DeGregori, J, Kowalik, T
Wu, CL, Magae, J, Illenye, S, Heintz, NH, Wells, JM
Tretiakova, A, Kundu, M, Gallia, GL, Khalili, K, Giordano, A, Shcherbik, N, Darbinian, N
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