DHFR gene expression is stimulated by E2F1

Stable Identifier
R-HSA-8961874
Type
Reaction [omitted]
Species
Homo sapiens
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E2F1 directly stimulates transcription of the DHFR gene, encoding dihydrofolate reductase. DHFR is involved in folate metabolism and synthesis of DNA bases (DeGregori et al. 1995, Wells et al. 1997, Darbinian et al. 1999).

Literature References
PubMed ID Title Journal Year
9020173 Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition

Wells, JM, Illenye, S, Magae, J, Wu, CL, Heintz, NH

J. Biol. Chem. 1997
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

DeGregori, J, Kowalik, T, Nevins, JR

Mol Cell Biol 1995
10597240 Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1

Darbinian, N, Gallia, GL, Kundu, M, Shcherbik, N, Tretiakova, A, Giordano, A, Khalili, K

Oncogene 1999
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