DHFR gene expression is stimulated by E2F1

Stable Identifier
R-HSA-8961874
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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DHFR gene expression is stimulated by E2F1
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E2F1 directly stimulates transcription of the DHFR gene, encoding dihydrofolate reductase. DHFR is involved in folate metabolism and synthesis of DNA bases (DeGregori et al. 1995, Wells et al. 1997, Darbinian et al. 1999).

Literature References
PubMed ID Title Journal Year
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

Nevins, JR, DeGregori, J, Kowalik, T

Mol Cell Biol 1995
9020173 Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition

Wu, CL, Magae, J, Illenye, S, Heintz, NH, Wells, JM

J. Biol. Chem. 1997
10597240 Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1

Tretiakova, A, Kundu, M, Gallia, GL, Khalili, K, Giordano, A, Shcherbik, N, Darbinian, N

Oncogene 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:TFDP1,TFDP2 [nucleoplasm]
Authored
Gopinathrao, G  (2004-06-16)
Reviewed
Bosco, G  (2004-06-16)
Created
Orlic-Milacic, M  (2017-02-06)
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