E2F1 directly stimulates transcription of the ORC1 gene (Ohtani et al. 1996, Ohtani et al. 1998). E2F1 regulated expression of Orc1 stimulates ORC1-6 complex formation and binding to the origin of replication in Drosophila (Asano and Wharton, 1999).
Ohtani, K, Ikeda, M, Nakamura, M, Tsujimoto, A
Leone, G, Nevins, JR, DeGregori, J, Ohtani, K, Herendeen, DR, Kelly, TJ
Asano, M, Wharton, RP
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