ORC1 gene expression is stimulated by E2F1

Stable Identifier
R-HSA-8961678
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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ORC1 gene expression is stimulated by E2F1
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E2F1 directly stimulates transcription of the ORC1 gene (Ohtani et al. 1996, Ohtani et al. 1998). E2F1 regulated expression of Orc1 stimulates ORC1-6 complex formation and binding to the origin of replication in Drosophila (Asano and Wharton, 1999).

Literature References
PubMed ID Title Journal Year
9778043 Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.

Ohtani, K, Ikeda, M, Nakamura, M, Tsujimoto, A

Oncogene 1998
8943353 Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor

Leone, G, Nevins, JR, DeGregori, J, Ohtani, K, Herendeen, DR, Kelly, TJ

Mol Cell Biol 1996
10228158 E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila

Asano, M, Wharton, RP

EMBO J 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
E2F1:TFDP1,TFDP2:ORC1 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:TFDP1,TFDP2 [nucleoplasm]
Authored
Gopinathrao, G  (2004-06-16)
Reviewed
Bosco, G  (2004-06-16)
Created
Orlic-Milacic, M  (2017-02-03)
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