E2F1 directly stimulates transcription of the ORC1 gene (Ohtani et al. 1996, Ohtani et al. 1998). E2F1 regulated expression of Orc1 stimulates ORC1-6 complex formation and binding to the origin of replication in Drosophila (Asano and Wharton, 1999).
Ohtani, K, DeGregori, J, Leone, G, Herendeen, DR, Kelly, TJ, Nevins, JR
Ohtani, K, Tsujimoto, A, Ikeda, M, Nakamura, M
Asano, M, Wharton, RP
© 2021 Reactome