Reactome | E2F1 binds the PCNA gene promoter

E2F1 binds the PCNA gene promoter

Stable Identifier

R-HSA-8961651

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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E2F1 binds to E2F binding sites in the promoter of the PCNA gene, encoding the proliferating cell nuclear antigen, a component of the DNA polymerase complex involved in eukaryotic DNA replication (DeGregori et al. 1995, Li et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
7623816	Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes Nevins, JR, DeGregori, J, Kowalik, T	Mol Cell Biol	1995
12782299	An E2F site in the 5'-promoter region contributes to serum-dependent up-regulation of the human proliferating cell nuclear antigen gene Lu, CD, Li, YY, Wang, L	FEBS Lett.	2003

Participants

Input

Output

E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

G1/S-Specific Transcription (Homo sapiens)

Authored

Gopinathrao, G (2004-06-16)

Reviewed

Bosco, G (2004-06-16)

Created

Orlic-Milacic, M (2017-02-04)

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