E2F1 binds the CDC6 gene promoter

Stable Identifier
R-HSA-8961620
Type
Reaction [binding]
Species
Homo sapiens
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E2F1 binds to E2F binding sites in the promoter of the CDC6 gene (Yan et al., 1998; Ohtani et al., 1998). CDC6 is required to recruit the MCM2-7 replication helicases.

Literature References
PubMed ID Title Journal Year
9520412 Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.

Yan, Z, DeGregori, J, Shohet, R, Leone, G, Stillman, B, Nevins, JR, Williams, RS

Proc Natl Acad Sci U S A 1998
9778043 Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.

Ohtani, K, Tsujimoto, A, Ikeda, M, Nakamura, M

Oncogene 1998
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