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RLBP1:11cRAL dissociates
Stable Identifier
R-HSA-8960973
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
The canonical retinoid cycle in rods (twilight vision) (Homo sapiens)
RLBP1:11cRAL dissociates (Homo sapiens)
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Interphotoreceptor retinoid-binding protein (RBP3) is the major soluble protein in the interphotoreceptor matrix (IPM) (Liou et al. 1989, Fong & Bridges 1988). It is thought to shuttle 11-cis-retinal (11cRAL) between retinal pigment epithelium (RPE) and photoreceptor outer segments during the visual cycle but the mechanism is poorly understood (Gonzalez-Fernandez & Ghosh 2008). It is assumed cellular retinaldehyde-binding protein (RLBP1) must dissociate from 11cRAL before 11cRAL is transported as RLBP1 is not present in photoreceptor cells.
Literature References
PubMed ID
Title
Journal
Year
3170584
Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA
Bridges, CD
,
Fong, SL
J. Biol. Chem.
1988
2542268
Human interstitial retinoid-binding protein. Gene structure and primary structure
Geng, L
,
Zhu, C
,
Liou, GI
,
Ma, DP
,
Baehr, W
,
Yang, YW
J. Biol. Chem.
1989
Participants
Input
RLBP1:11cRAL [cytosol]
(Homo sapiens)
Output
11cRAL [cytosol]
RLBP1 [cytosol]
(Homo sapiens)
Participates
as an event of
The canonical retinoid cycle in rods (twilight vision) (Homo sapiens)
Orthologous Events
RLBP1:11cRAL dissociates (Bos taurus)
RLBP1:11cRAL dissociates (Canis familiaris)
RLBP1:11cRAL dissociates (Danio rerio)
RLBP1:11cRAL dissociates (Dictyostelium discoideum)
RLBP1:11cRAL dissociates (Drosophila melanogaster)
RLBP1:11cRAL dissociates (Gallus gallus)
RLBP1:11cRAL dissociates (Mus musculus)
RLBP1:11cRAL dissociates (Rattus norvegicus)
RLBP1:11cRAL dissociates (Sus scrofa)
RLBP1:11cRAL dissociates (Xenopus tropicalis)
Authored
Jassal, B (2017-02-02)
Reviewed
D'Eustachio, P (2017-02-06)
Created
Jassal, B (2017-02-02)
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