Reactome | VGF [endoplasmic reticulum lumen]

VGF [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956769

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Neurosecretory protein VGF component recommendedName: Neuroendocrine regulatory peptide-1, VGF_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        VGF gene expression (Homo sapiens)
        
        VGF [endoplasmic reticulum lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15240 VGF

Gene Names

VGF

Chain

signal peptide:1-22, chain:23-615, peptide:281-306, peptide:310-347, peptide:554-615, peptide:554-577, peptide:554-574

Reference Genes

BioGPS Gene:7425 VGF

COSMIC (genes):VGF VGF

CTD Gene:7425 VGF

dbSNP Gene:7425 VGF

ENSEMBL:ENSG00000128564 VGF

HGNC:12684 VGF

KEGG:hsa:7425 VGF

Monarch:7425 VGF

NCBI Gene:7425 VGF

OMIM:602186 VGF

UCSC:O15240 VGF

Reference Transcript

Other Identifiers

11720026_a_at

11720027_x_at

17060824

3064463

3064464

3064465

3064466

3064467

3064468

3064469

3064470

3064471

3064472

3064473

3064474

3064475

3064476

3064477

3064479

32969_r_at

59503_at

7425

8141664

A_24_P129326

A_33_P3276703

GE81270

GO:0001541

GO:0002021

GO:0005179

GO:0005184

GO:0005576

GO:0005615

GO:0005788

GO:0005794

GO:0006091

GO:0007165

GO:0008083

GO:0009409

GO:0019953

GO:0022414

GO:0030073

GO:0030133

GO:0031410

GO:0032868

GO:0033500

GO:0042593

GO:0042742

GO:0043226

GO:0043231

GO:0048018

GO:0048167

GO:0048856

GO:0051591

GO:0098542

GO:0098772

HMNXSV003053787

ILMN_1757497

PH_hs_0010239

TC07001683.hg

TC07003087.hg

Participates

as an output of

VGF gene expression (Homo sapiens)

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

p-VGF [endoplasmic reticulum lumen]

Inferred To

Vgf [endoplasmic reticulum lumen] (Mus musculus)

Vgf [endoplasmic reticulum lumen] (Rattus norvegicus)

VGF [endoplasmic reticulum lumen] (Bos taurus)

VGF [endoplasmic reticulum lumen] (Canis familiaris)

VGF [endoplasmic reticulum lumen] (Sus scrofa)

Cross References

RefSeq

XP_054214910.1, XP_016868068.1, XP_011514851.1, XP_054214912.1, XP_005250618.1, NP_003369.2, XP_054214911.1

ENSEMBL

ENSG00000128564, ENSP00000400884, ENST00000249330, ENSP00000249330, ENST00000445482

OpenTargets

ENSG00000128564

GeneCards

VGF

HPA

ENSG00000128564-VGF

PRO

O15240

Pharos - Targets

O15240

GlyGen

O15240

PDB

7D16, 7D13, 8H0U, 8H0G

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01160 NPPA	5	NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2