YAP1 binds TP73

Stable Identifier
R-HSA-8956676
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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YAP1 binds TP73
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YAP1, phosphorylated on tyrosine residue Y407 (Y357 in the splicing isoform 3, known as YAP1-1beta) by the protein tyrosine kinase ABL1, activated in response to DNA damage, forms a complex with TP73. ABL1-phosphorylated YAP1 can no longer bind RUNX1 (Levy, Adamovich et al. 2008; Levy, Reuven and Shaul 2008). Binding of phosphorylated YAP1 to TP73 may target TP73 to promoters of pro-apoptotic target genes instead of cell cycle arrest genes (Levy, Adamovich et al. 2008).
Literature References
PubMed ID Title Journal Year
18701449 A regulatory circuit controlling Itch-mediated p73 degradation by Runx

Shaul, Y, Reuven, N, Levy, D

J. Biol. Chem. 2008
18280240 Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

Shaul, Y, Reuven, N, Adamovich, Y, Levy, D

Mol. Cell 2008
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Orthologous Events
YAP1 binds TP73 (Bos taurus)
YAP1 binds TP73 (Danio rerio)
YAP1 binds TP73 (Gallus gallus)
YAP1 binds TP73 (Mus musculus)
YAP1 binds TP73 (Rattus norvegicus)
YAP1 binds TP73 (Sus scrofa)
YAP1 binds TP73 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2017-01-24)
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