YAP1, phosphorylated on tyrosine residue Y407 (Y357 in the splicing isoform 3, known as YAP1-1beta) by the protein tyrosine kinase ABL1, activated in response to DNA damage, forms a complex with TP73. ABL1-phosphorylated YAP1 can no longer bind RUNX1 (Levy, Adamovich et al. 2008; Levy, Reuven and Shaul 2008). Binding of phosphorylated YAP1 to TP73 may target TP73 to promoters of pro-apoptotic target genes instead of cell cycle arrest genes (Levy, Adamovich et al. 2008).