ITCH gene expression is stimulated by RUNX1 and YAP1

Stable Identifier
R-HSA-8956652
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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ITCH gene expression is stimulated by RUNX1 and YAP1
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Expression of the ITCH gene, encoding the E3 ubiquitin-protein ligase ITCH, is directly stimulated by binding of the complex of RUNX1 and YAP1 to the ITCH promoter (Levy, Reuven and Shaul 2008).
ITCH is an important regulator of hematopoietic stem cell (HSC) function and homeostasis. ITCH reduces the proliferation rate of HSCs by downregulating NOTCH1 (Rathinam et al. 2011).
Literature References
PubMed ID Title Journal Year
18701449 A regulatory circuit controlling Itch-mediated p73 degradation by Runx

Shaul, Y, Reuven, N, Levy, D

J. Biol. Chem. 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:YAP1:ITCH gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB:YAP1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2017-01-24)
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