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The complex of RUNX1 and YAP1 binds the ITCH gene promoter
Stable Identifier
R-HSA-8956649
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
The complex of RUNX1 and YAP1 binds the ITCH gene promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The complex of RUNX1, presumably associated with CBFB, and YAP1 binds the promoter of the ITCH gene, encoding the E3 ubiquitin-protein ligase ITCH (Levy, Reuven and Shaul 2008).
Literature References
PubMed ID
Title
Journal
Year
18701449
A regulatory circuit controlling Itch-mediated p73 degradation by Runx
Shaul, Y
,
Reuven, N
,
Levy, D
J. Biol. Chem.
2008
Participants
Input
ITCH gene [nucleoplasm]
(Homo sapiens)
RUNX1:CBFB:YAP1 [nucleoplasm]
(Homo sapiens)
Output
RUNX1:CBFB:YAP1:ITCH gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
Authored
Orlic-Milacic, M (2016-09-14)
Reviewed
Chuang, LS (2016-12-20)
Ito, Y (2016-12-20)
Created
Orlic-Milacic, M (2017-01-24)
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