RUNX1-containing TAL1 complex binds the MYB gene enhancer

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The TAL1 complex containing GATA3, RUNX1 and CBFB binds the MYB gene enhancer element (Sanda et al. 2012, Mansour et al. 2014). Binding of the RUNX1-containing TAL1 complex to the MYB gene enhancer can be facilitated by the presence of the MYB transcription factor (Mansour et al. 2014).

Literature References
PubMed ID Title Journal Year
25394790 Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Sallan, SE, Hunger, SP, Mansour, MR, Lawton, L, Berezovskaya, A, Etchin, J, Anders, L, Sanda, T, Durbin, AD, Look, AT, Young, RA, Silverman, LB, Abraham, BJ, Gutierrez, A, Loh, ML

Science 2014
22897851 Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia

Kelliher, MA, Ma, W, Barrasa, MI, Tatarek, J, Sanda, T, Look, AT, Fan, ZP, Young, RA, Jamieson, CH, Lawton, LN, Ahn, Y, Gutierrez, A, Kohlhammer, H, Staudt, LM

Cancer Cell 2012
Cite Us!