RUNX1 binds the core TAL1 complex

Stable Identifier
Reaction [binding]
Homo sapiens
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RUNX1, in complex with CBFB, binds to the core TAL1 complex consisting of TAL1 (SCL), TCF3 (E2A) or TCF12 (HEB), LMO1 or LMO2, LDB1 and GATA1, GATA2 or GATA3 (Wilson et al. 2010, Tijssen et al. 2011, Sanda et al. 2012, Mansour et al. 2014, Hoang et al. 2016). Assembly of the RUNX1- and GATA3-containing TAL1 complex is positively regulated by the CDK7-containing CAK complex (Kwiatkowski et al. 2014).
Literature References
PubMed ID Title Journal Year
25043025 Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Brown, JR, Marto, JA, Sim, T, Kim, ND, Dastur, A, Zhang, T, Kwiatkowski, N, Ramaswamy, S, Benes, CH, Look, T, Hannett, NM, Jenkins, CE, Mitsiades, CS, Amzallag, A, Sanda, T, Young, RA, Abraham, BJ, Ficarro, SB, Tesar, B, Reddy, J, McMillin, D, Weng, AP, Gray, NS, Rahl, PB

Nature 2014
25394790 Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Sallan, SE, Hunger, SP, Mansour, MR, Lawton, L, Berezovskaya, A, Etchin, J, Anders, L, Sanda, T, Durbin, AD, Look, AT, Young, RA, Silverman, LB, Abraham, BJ, Gutierrez, A, Loh, ML

Science 2014
20887958 Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators

Schütte, J, Pimanda, JE, Göttgens, B, Foster, SD, Dzierzak, E, Chilarska, PM, de Bruijn, MF, Ouwehand, WH, Wang, X, Kaimakis, P, Knezevic, K, Kinston, S, Wilson, NK

Cell Stem Cell 2010
21571218 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators

Tijssen, MR, Cvejic, A, Ottersbach, K, Joshi, A, Hannah, RL, Göttgens, B, Forrai, A, Ouwehand, WH, Wang, X, Ferreira, R, Stemple, DL, Smethurst, PA, Oram, SH, Green, AR, Wilson, NK, Bellissimo, DC

Dev. Cell 2011
22897851 Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia

Kelliher, MA, Ma, W, Barrasa, MI, Tatarek, J, Sanda, T, Look, AT, Fan, ZP, Young, RA, Jamieson, CH, Lawton, LN, Ahn, Y, Gutierrez, A, Kohlhammer, H, Staudt, LM

Cancer Cell 2012
27137657 SCL/TAL1 in Hematopoiesis and Cellular Reprogramming

Martin, R, Hoang, T, Lambert, JA

Curr. Top. Dev. Biol. 2016
This event is regulated
Positively by
Orthologous Events
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