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LDB1 [nucleoplasm]
Stable Identifier
R-HSA-8956515
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
LIM domain-binding protein 1, LDB1_HUMAN, CLIM2, Carboxyl-terminal LIM domain-binding protein 2
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Cardiogenesis (Homo sapiens)
Expression of HAND2 in cardiogenesis (Homo sapiens)
GATA4:GATA6:ISL1:LDB1:HAND2 gene [nucleoplasm] (Homo sapiens)
ISL1:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
Expression of MEF2C in cardiogenesis (Homo sapiens)
GATA4:ISL1:LDB1:NKX2-5:TBX20:MEF2C gene [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
GATA4, GATA6, and ISL1:LDB1 bind the HAND2 gene (Homo sapiens)
GATA4:GATA6:ISL1:LDB1:HAND2 gene [nucleoplasm] (Homo sapiens)
ISL1:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
GATA4, ISL1:LDB1, TBX20, and NKX2-5 bind the MEF2C gene (Homo sapiens)
GATA4:ISL1:LDB1:NKX2-5:TBX20:MEF2C gene [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
ISL1 binds the SLIT2 gene enhancer (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1:SLIT2 gene [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
SLIT2 gene expression is stimulated by ISL1 (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1:SLIT2 gene [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
RUNX1 binds the core TAL1 complex (Homo sapiens)
RUNX1:CBFB:TAL1 core complex [nucleoplasm] (Homo sapiens)
TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
Sensory Perception (Homo sapiens)
Olfactory Signaling Pathway (Homo sapiens)
Expression and translocation of olfactory receptors (Homo sapiens)
Expression of Olfactory Receptor (Homo sapiens)
EBF1:LDB1:LHX2:Intergenic olfactory enhancer:Olfactory Receptor gene [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
LHX2, LDB1, and EBF1 bind Olfactory Receptor gene and intergenic olfactory enhancers (Homo sapiens)
EBF1:LDB1:LHX2:Intergenic olfactory enhancer:Olfactory Receptor gene [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
LDB1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86U70 LDB1
Gene Names
LDB1, CLIM2
Chain
initiator methionine:, chain:2-411
Reference Genes
BioGPS Gene:8861 LDB1
COSMIC (genes):LDB1 LDB1
CTD Gene:8861 LDB1
dbSNP Gene:8861 LDB1
ENSEMBL:ENSG00000198728 LDB1
HGNC:6532 LDB1
KEGG:hsa:8861 LDB1
Monarch:8861 LDB1
NCBI Gene:8861 LDB1
OMIM:603451 LDB1
UCSC:Q86U70 LDB1
Reference Transcript
RefSeq:NM_003893.4 LDB1
RefSeq:NM_001113407.2 LDB1
Participates
as a component of
GATA4:ISL1:LDB1:NKX2-5:TBX20:MEF2C gene [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
TAL1 core complex [nucleoplasm] (Homo sapiens)
LDB1 homodimer [nucleoplasm] (Homo sapiens)
Inferred To
LDB1 [nucleoplasm]
(Bos taurus)
LDB1 [nucleoplasm]
(Canis familiaris)
LDB1 [nucleoplasm]
(Gallus gallus)
LDB1 [nucleoplasm]
(Sus scrofa)
Chi [nucleoplasm]
(Drosophila melanogaster)
Ldb1 [nucleoplasm]
(Mus musculus)
Ldb1 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000354616
,
ENST00000361198
,
ENSP00000501277
,
ENSG00000198728
,
ENST00000673968
OpenTargets
ENSG00000198728
GeneCards
LDB1
HPA
ENSG00000198728-LDB1
PRO
Q86U70
Pharos - Targets
Q86U70
GlyGen
Q86U70
PDB
8HIB
,
2XJZ
,
2XJY
,
7OB8
,
7OB5
,
2YPA
,
6TYD
,
9F5B
,
8SSU
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17542 TAL1
1
TAL1 [nucleoplasm]
(R-HSA-8956511)
0.69
4
UniProt:P50458 LHX2
1
LHX2 [nucleoplasm]
(R-HSA-9011100)
0.594
3
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