RETSAT reduces atROL to at-13,14-dhROL

Stable Identifier
R-HSA-8956427
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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RETSAT reduces atROL to at-13,14-dhROL
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All-trans-retinol 13,14-reductase (RETSAT) is an ER membrane-associated protein that mediates the saturation of the 13-14 double bond of all-trans-retinol (atROL) to produce all-trans-13,14-dihydroretinol (at-13,14-dhROL). The product formed is a metabolite of unknown biological function. The human activity of RETSAT is inferred from mouse Retsat enzyme assays (Moise et al. 2004). In human and mouse, RETSAT is induced during adipogenesis and is directly regulated by the transcription factor peroxisome proliferator activated receptor gamma (PPAR-gamma). Ablation of RETSAT inhibits adipogenesis but this block was not overcome by the product of RETSAT enzymatic activity. In adipose tissue, RETSAT is expressed in adipocytes but is downregulated in obesity. RETSAT could be a novel target for therapeutic intervention in metabolic disease (Schupp et al. 2009).
Literature References
PubMed ID Title Journal Year
15358783 Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase

Moise, AR, Kuksa, V, Imanishi, Y, Palczewski, K

J. Biol. Chem. 2004
19139408 Retinol saturase promotes adipogenesis and is downregulated in obesity

Schupp, M, Lefterova, MI, Janke, J, Leitner, K, Cristancho, AG, Mullican, SE, Qatanani, M, Szwergold, N, Steger, DJ, Curtin, JC, Kim, RJ, Suh, MJ, Suh, M, Albert, MR, Engeli, S, Gudas, LJ, Lazar, MA

Proc. Natl. Acad. Sci. U.S.A. 2009
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Output
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Catalyst Activity

all-trans-retinol 13,14-reductase activity of RETSAT [endoplasmic reticulum membrane]

Physical Entity
RETSAT [endoplasmic reticulum membrane] (Homo sapiens)
Activity
all-trans-retinol 13,14-reductase activity (GO:0051786)
Inferred From
Retsat reduces atROL to at-13,14-dhROL (Mus musculus)
Authored
Jassal, B  (2017-01-23)
Reviewed
D'Eustachio, P  (2017-01-30)
Created
Jassal, B  (2017-01-23)
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