ZBED1 (DREF) SUMOylates CHD3 with SUMO1

Stable Identifier
R-HSA-8956365
Type
Reaction
Species
Homo sapiens
Compartment
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ZBED1 (hDREF) SUMOylates CHD3 (Mi2alpha) at lysine-1971 with SUMO1 (Yamashita et al. 2016). SUMOylation leads to dissociation of CHD3 from chromatin and suppresses transcriptional repression by CHD3.

Literature References
PubMed ID Title Journal Year
27068747 Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α

Yamashita, D, Moriuchi, T, Osumi, T, Hirose, F

J. Biol. Chem. 2016
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of ZBED1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created