ZBED1 (DREF) SUMOylates CHD3 with SUMO1

Stable Identifier
R-HSA-8956365
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ZBED1 (DREF) SUMOylates CHD3 with SUMO1
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ZBED1 (hDREF) SUMOylates CHD3 (Mi2alpha) at lysine-1971 with SUMO1 (Yamashita et al. 2016). SUMOylation leads to dissociation of CHD3 from chromatin and suppresses transcriptional repression by CHD3.

Literature References
PubMed ID Title Journal Year
27068747 Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α

Osumi, T, Yamashita, D, Hirose, F, Moriuchi, T

J. Biol. Chem. 2016
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of ZBED1 [nucleoplasm]

Physical Entity
ZBED1 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Caenorhabditis elegans)
ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Xenopus tropicalis)
Authored
Yang, WC  (2017-01-22)
Lu, J  (2017-01-22)
Reviewed
Matunis, MJ  (2017-01-22)
Created
May, B  (2017-01-22)
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