Translation of DCUN1D3 is inhibited by PUM2

Stable Identifier
R-HSA-8956234
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Translation of DCUN1D3 is inhibited by PUM2
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PUM2 is a sequence-specific RNA binding protein that binds DCUN1D3 mRNA and decreases levels of mature DCUN1D3 protein, likely by promoting mRNA degradation (Galgano et al, 2008; Huang et al, 2014).
Literature References
PubMed ID Title Journal Year
18776931 Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system

Galgano, A, Forrer, M, Jaskiewicz, L, Kanitz, A, Zavolan, M, Gerber, AP

PLoS ONE 2008
25349211 SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1)

Huang, G, Stock, C, Bommeljé, CC, Weeda, VB, Shah, K, Bains, S, Buss, E, Shaha, M, Rechler, W, Ramanathan, SY, Singh, B

J. Biol. Chem. 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PUM2:DCUN1D3 mRNA [cytosol] (Homo sapiens)
Active Unit
PUM2 [cytosol]
Authored
Rothfels, K  (2016-12-13)
Reviewed
Pick, E  (2017-02-22)
Created
Rothfels, K  (2017-01-19)
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