NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1

Stable Identifier
R-HSA-8956050
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CUL7, CCDC8 and OBSL1 are part of a 3M complex that has roles in maintenace of genome stability and microtubule dynamics (Li et al, 2014; Yan et al, 2014). The 3M complex inhibits CUL9-mediated ubiquitination of BIRC5 through the formation of a CUL9:CUL7 heterodimer (Skaar et al, 2007; Li et al, 2014)

Literature References
PubMed ID Title Journal Year
17332328 PARC and CUL7 form atypical cullin RING ligase complexes

Tron, A, Florens, L, Tsutsumi, T, Skaar, JR, Swanson, SK, Arai, T, DeCaprio, JA, Washburn, MP

Cancer Res. 2007
24793695 The 3M complex maintains microtubule and genome integrity

Yu, Y, Chen, X, Sinnott, B, Yan, J, Li, Z, Xiong, Y, Yan, F, Cormier-Daire, V, Cappell, KM, Whitehurst, AW, Mo, J, Duncan, JA

Mol. Cell 2014
24793696 CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity

Pei, XH, Yan, J, Li, Z, Xiong, Y, Yan, F, Cappell, KM, Whitehurst, AW

Mol. Cell 2014
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