NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CUL9 (also known as PARC for p53-associated PARkin-like cytoplasmic protein) is an atypical cullin that has been shown to form a ubiquitin ligase complex with RBX1, although other components of the putative CRL9 complex have not yet been identified (Skaar et al, 2007; Li et al, 2014). CUL9:RBX1 is neddylated in vivo, likely through the UBE2M E2 although this hasn't been directly demonstrated (Skaar et al, 2007).
CUL9 is 60% identical to CUL7, another atypical mammalian cullin family member, but more distantly related to CUL1, 2, 3, 4A,4B and 5. CUL9 and CUL7 have been shown to form a heterodimer in vivo, and both interact with p53 (Skaar et al, 2007; Andrews et al, 2006; Nikolaev et al, 2003). CUL9 ubiquitinates BIRC5 (also known as Survivin), a protein with roles in cellular proliferation and inhibition of apoptosis. CUL9-mediated ubiquitination of BIRC5 is inhibited by the 3M complex, which consists of CUL7, CCDC8 and OBSL1 (Li et al, 2014).
Literature References
PubMed ID Title Journal Year
12526791 Parc: a cytoplasmic anchor for p53

Gu, W, Nikolaev, AY, Qin, J, Puskas, N, Li, M

Cell 2003
17332328 PARC and CUL7 form atypical cullin RING ligase complexes

Tron, A, Florens, L, Tsutsumi, T, Skaar, JR, Swanson, SK, Arai, T, DeCaprio, JA, Washburn, MP

Cancer Res. 2007
16547496 Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function

He, YJ, Andrews, P, Xiong, Y

Oncogene 2006
24793696 CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity

Pei, XH, Yan, J, Li, Z, Xiong, Y, Yan, F, Cappell, KM, Whitehurst, AW

Mol. Cell 2014
Orthologous Events
Cite Us!