Reactome | CUL9:RBX1 ubiquitinates BIRC5

CUL9:RBX1 ubiquitinates BIRC5

Stable Identifier

R-HSA-8956026

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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One defined target of CUL9 ubiquitin ligase is BIRC5 (also known as Survivin), which has roles in cellular proliferation, inhibition of apoptosis and maintenance of genome stability (Zhao et al, 2000; Watanabe, 2010). Deletion of CUL9 leads to polyploidy, abnormal nuclear morphology and DNA damage and is accompanied by an increase in survivin protein levels (Li et al, 2014). CUL9-mediated ubiquitination of BIRC5 is negatively regulated by the 3M complex, consisting of CUL7, CCDC8 and OBSL1 (Li et al, 2014; Yan et al, 2014). This CUL7-dependent inhibition of CUL9 ubiquitin ligase activity is promoted by heterodimerization between CUL7 and CUL9 (Li et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
24793695	The 3M complex maintains microtubule and genome integrity Yu, Y, Chen, X, Sinnott, B, Yan, J, Li, Z, Xiong, Y, Yan, F, Cormier-Daire, V, Cappell, KM, Whitehurst, AW, Mo, J, Duncan, JA	Mol. Cell	2014
24793696	CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity Pei, XH, Yan, J, Li, Z, Xiong, Y, Yan, F, Cappell, KM, Whitehurst, AW	Mol. Cell	2014
21447816	Temporal and spatial regulation of targeting aurora B to the inner centromere Watanabe, Y	Cold Spring Harb. Symp. Quant. Biol.	2010
11069780	The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner Downward, J, Lemoine, NR, Martins, LM, Tenev, T, Zhao, J	J. Cell. Sci.	2000